Bioequivalence and Bioavailability Forum

“Punkteinwaage” [Bioanalytics]

posted by Helmut  – Vienna, Austria, 2017-02-23 16:41 (3413 d 01:08 ago) – Posting: # 17100
Views: 14,062

Hi Relaxation,

❝ I am also not aware of any guideline giving a requirement that there should be different concentrations.

There is none.

❝ is there really any rule, that CC and QC concentrations have to differ at all? And why would it be common sense, that they should be different, as long as I do not use the same stock solution?

❝ I just can't see a reason (but I am also by no means a bioanalyst).

I was an analytical chemist.
If you use different stock solutions you would get identical concentrations only if the analyst managed to achieve a <lang="de"> Punkteinwaage </lang="de"> (sorry, don’t know the English term), i.e., weigh-in identical – desired – amounts. Since this is very difficult, it is common sense that concentrations of calibrators and QCs generally differ (slightly).

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

• Calibration and QC point with same concentration Ladi 2017-02-23 02:58 
  • Calibration and QC point with same concentration Ohlbe 2017-02-23 10:21
  • Calibration and QC point with same concentration Relaxation 2017-02-23 15:24
    • “Punkteinwaage”Helmut 2017-02-23 15:41
      • “Punkteinwaage” Ohlbe 2017-02-23 16:15
    • Calibration and QC point with same concentration Ohlbe 2017-02-23 16:20
      • Calibration and QC point with same concentration Relaxation 2017-02-23 17:29
        • Calibration and QC point with same concentration ElMaestro 2017-02-23 22:02
        • Calibration and QC point with same concentration Ladi 2017-02-24 05:50
          • Calibration and QC point with same concentration Relaxation 2017-02-24 10:29
          • Calibration and QC point with same concentration Helmut 2017-02-24 12:11
            • OT: Beauty of science d_labes 2017-02-24 13:17
            • Calibration and QC point with same concentration ElMaestro 2017-02-24 14:05
              • Beauty is in the eye of the beholder Helmut 2017-03-03 16:06
                • Beauty is in the eye of the beholder ElMaestro 2017-03-03 20:18