Training required [Bioanalytics]

posted by Helmut Homepage – Vienna, Austria, 2016-03-17 17:18 (3359 d 09:47 ago) – Posting: # 16112
Views: 5,229

Hi Mohamed,

❝ I am writing from Egypt […] this apparently came from a new member who joined the BE Evaluation committee.


… who apparently has not completed his training yet. SCNR. :-D

❝ I welcome other comments from members.


I fully agree with Ohlbe. In assessing (in)accuracy/(im)precision of bioanalytical methods we are only interested in back-calculated concentrations. Haven’t seen anything else in 30+ years.

Since you wanted a reference, see how the EMA’s BMV-GL defines the LLOQ:

The lower limit of quantification (LLOQ) is the lowest concentration of analyte in a sample which can be quantified reliably, with an acceptable accuracy and precision.

See also what the GL says about the calibration curve and accuracy.
(Back calculated) concentrations. Period.

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
23,424 posts in 4,927 threads, 1,674 registered users;
67 visitors (0 registered, 67 guests [including 12 identified bots]).
Forum time: 04:05 CEST (Europe/Vienna)

It’s difficult to work in a group
when you are omnipotent.    John de Lancie (as Q)

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5