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RegisterChange in curve changed the ratio of Cmax [Bioanalytics]
Dear Compliance
Again: If you use a different method the absolute concentratiosn measured in the samples can be different from method to method since bioanalytical methods are "semi-quantitative". However, if both methods are accurate and precise the slope of the curve should not be different i.e. the ratio of Cmax should be the same. When applying another method all samples are affected in the same way, there can not be a difference between test and reference samples. It is therefore absolute unlogical to have a shift in Cmax from 102% to 87% without having differences in method performance.
Kind regards
Dr_Dan
❝ Please note that the difference between the concentration obtain during initial analysis and repeat analysis is around 10-12%.
Again: If you use a different method the absolute concentratiosn measured in the samples can be different from method to method since bioanalytical methods are "semi-quantitative". However, if both methods are accurate and precise the slope of the curve should not be different i.e. the ratio of Cmax should be the same. When applying another method all samples are affected in the same way, there can not be a difference between test and reference samples. It is therefore absolute unlogical to have a shift in Cmax from 102% to 87% without having differences in method performance.
Kind regards
Dr_Dan
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Kind regards and have a nice day
Dr_Dan
Kind regards and have a nice day
Dr_Dan
Complete thread:
- Change in curve changed the ratio of Cmax Compliance 2015-03-23 07:39
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Change in curve changed the ratio of Cmax Dr_Dan 2015-03-23 08:59
- Change in curve changed the ratio of Cmax Compliance 2015-03-23 09:27
- Change in curve changed the ratio of Cmax nobody 2015-03-23 09:19
- Change in curve changed the ratio of Cmax Compliance 2015-03-23 10:09
- Change in curve changed the ratio of Cmax nobody 2015-03-23 10:34
- Change in curve changed the ratio of Cmax Compliance 2015-03-23 10:53
- Change in curve changed the ratio of Cmax nobody 2015-03-23 10:34
- Change in curve changed the ratio of Cmax Compliance 2015-03-23 10:09
- Change in curve changed the ratio of Cmax Ohlbe 2015-03-23 14:13
- Change in curve changed the ratio of Cmax Compliance 2015-03-23 15:29
- Change in curve changed the ratio of Cmax nobody 2015-03-23 16:11
- Change in curve changed the ratio of Cmax Compliance 2015-03-23 15:29
- Change in curve changed the ratio of CmaxDr_Dan 2015-03-24 08:15
- Change in curve changed the ratio of Cmax Compliance 2015-03-24 09:39
- Change in curve changed the ratio of Cmax Dr_Dan 2015-03-24 11:05
- Change in curve changed the ratio of Cmax Compliance 2015-03-25 12:13
- Change in curve changed the ratio of Cmax Dr_Dan 2015-03-23 08:59
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