Change in curve changed the ratio of Cmax [Bioanalytics]

posted by Compliance – India, 2015-03-23 11:53 (4116 d 09:16 ago) – Posting: # 14598
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❝ Do I get this right: You basically suggest that the improved LLOQ increased the number of samples >LLOQ and thereby Cmax statistics changed dramatically?


Yes. we assume that we will get full characterization and it happen.

❝ But AUC was largely unaffected?


AUC is also get affected as the data set pool increases due to less LLOQ with respect to previous one.

❝ Was the absolute slop unaffected by changing the calibration range? Did you change weighting factors for lin. regression?


Weighting factor for liner regression is same as previous i.e. 1/x2

❝ Hmm... really hard to say "no problem" based on spares data! ;-)


this is Meselamine and giving very hard time to me. :confused:

regards,

Compliance

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