Bioequivalence and Bioavailability Forum • Change in curve changed the ratio of Cmax

Change in curve changed the ratio of Cmax [Bioanalytics]

posted by Compliance – India, 2015-03-23 11:53 (3716 d 14:52 ago) – Posting: # 14598
Views: 12,396

❝ Do I get this right: You basically suggest that the improved LLOQ increased the number of samples >LLOQ and thereby Cmax statistics changed dramatically?

Yes. we assume that we will get full characterization and it happen.

❝ But AUC was largely unaffected?

AUC is also get affected as the data set pool increases due to less LLOQ with respect to previous one.

❝ Was the absolute slop unaffected by changing the calibration range? Did you change weighting factors for lin. regression?

Weighting factor for liner regression is same as previous i.e. 1/x2

❝ Hmm... really hard to say "no problem" based on spares data! ;-)

this is Meselamine and giving very hard time to me. :confused:

regards,

Compliance

Complete thread:

Change in curve changed the ratio of Cmax Compliance 2015-03-23 07:39
- Change in curve changed the ratio of Cmax Dr_Dan 2015-03-23 08:59
  - Change in curve changed the ratio of Cmax Compliance 2015-03-23 09:27
- Change in curve changed the ratio of Cmax nobody 2015-03-23 09:19
  - Change in curve changed the ratio of Cmax Compliance 2015-03-23 10:09
    - Change in curve changed the ratio of Cmax nobody 2015-03-23 10:34
      - Change in curve changed the ratio of CmaxCompliance 2015-03-23 10:53
- Change in curve changed the ratio of Cmax Ohlbe 2015-03-23 14:13
  - Change in curve changed the ratio of Cmax Compliance 2015-03-23 15:29
    - Change in curve changed the ratio of Cmax nobody 2015-03-23 16:11
- Change in curve changed the ratio of Cmax Dr_Dan 2015-03-24 08:15
  - Change in curve changed the ratio of Cmax Compliance 2015-03-24 09:39
- Change in curve changed the ratio of Cmax Dr_Dan 2015-03-24 11:05
  - Change in curve changed the ratio of Cmax Compliance 2015-03-25 12:13