Bioequivalence and Bioavailability Forum

Change in curve changed the ratio of Cmax [Bioanalytics]

posted by nobody – 2015-03-23 11:34 (4109 d 18:24 ago) – Posting: # 14597
Views: 14,191

Hi Compliance!

Do I get this right: You basically suggest that the improved LLOQ increased the number of samples >LLOQ and thereby Cmax statistics changed dramatically?

But AUC was largely unaffected?

Was the absolute slop unaffected by changing the calibration range? Did you change weighting factors for lin. regression?

Hmm... really hard to say "no problem" based on spares data!

Complete thread:

• Change in curve changed the ratio of Cmax Compliance 2015-03-23 07:39 
  • Change in curve changed the ratio of Cmax Dr_Dan 2015-03-23 08:59
    • Change in curve changed the ratio of Cmax Compliance 2015-03-23 09:27
  • Change in curve changed the ratio of Cmax nobody 2015-03-23 09:19
    • Change in curve changed the ratio of Cmax Compliance 2015-03-23 10:09
      • Change in curve changed the ratio of Cmaxnobody 2015-03-23 10:34
        • Change in curve changed the ratio of Cmax Compliance 2015-03-23 10:53
  • Change in curve changed the ratio of Cmax Ohlbe 2015-03-23 14:13
    • Change in curve changed the ratio of Cmax Compliance 2015-03-23 15:29
      • Change in curve changed the ratio of Cmax nobody 2015-03-23 16:11
  • Change in curve changed the ratio of Cmax Dr_Dan 2015-03-24 08:15
    • Change in curve changed the ratio of Cmax Compliance 2015-03-24 09:39
  • Change in curve changed the ratio of Cmax Dr_Dan 2015-03-24 11:05
    • Change in curve changed the ratio of Cmax Compliance 2015-03-25 12:13