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RegisterReuse of samples already extracted for repetition of a run [Bioanalytics]
Dear colleagues
Thank you for your opinions and, especially Ohlbe which, I think has got the gist the real problem.
No stats was made prior. We are only a laboratory of analytical determination and the PK statistics are made by the Sponsor. The instrument (LC-MS-MS) at about halfway began to respond abnormally and only in the morning we could realize what happened and an investigation was started.
The consequence was the QC failed in the second part of the run (when the instrumental response is changed), and consequently the entire run failed and should be repeated.
Having studied the stability of the samples after extraction, it was decided to reuse all them (CS, QS, unknown samples stored in the refrigerator) to repeat the run.
IMHO we decided correctly.
Yours truly
Roberto
Thank you for your opinions and, especially Ohlbe which, I think has got the gist the real problem.
No stats was made prior. We are only a laboratory of analytical determination and the PK statistics are made by the Sponsor. The instrument (LC-MS-MS) at about halfway began to respond abnormally and only in the morning we could realize what happened and an investigation was started.
The consequence was the QC failed in the second part of the run (when the instrumental response is changed), and consequently the entire run failed and should be repeated.
Having studied the stability of the samples after extraction, it was decided to reuse all them (CS, QS, unknown samples stored in the refrigerator) to repeat the run.
IMHO we decided correctly.
Yours truly
Roberto
Complete thread:
- Reuse of samples already extracted for repetition of a run Roberto 2015-02-19 16:51
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Reuse of samples already extracted for repetition of a run Ohlbe 2015-02-19 18:48
- Reuse of samples already extracted for repetition of a run Dr_Dan 2015-02-20 08:29
- Reuse of samples already extracted for repetition of a run Ohlbe 2015-02-20 09:39
- Reuse of samples already extracted for repetition of a run Dr_Dan 2015-02-20 08:29
- Reuse of samples already extracted for repetition of a run nobody 2015-02-20 11:58
- Reuse of samples already extracted for repetition of a runRoberto 2015-02-25 09:57
- Reuse of samples already extracted for repetition of a run Ohlbe 2015-02-19 18:48
Ing. Helmut Schütz