SAS vs. PHX/WNL [Bioanalytics]

posted by Helmut Homepage – Vienna, Austria, 2014-09-28 19:21 (3894 d 07:17 ago) – Posting: # 13606
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Hi to all,

❝ This could be the case if there is one or more subjects having some period data missing; didn't I read somewhere that WNL will do a max likelihood optimisation by default (=essentially a mixed model) whereas SAS will try Proc GLM (normal linear model).

❝ The mixed model versus normal linear model would explain the subtle difference which then isn't a matter of decimals carried.


Correct for WinNonlin. SAS doesn’t try “Proc GLM” – it will use it if stated in the code (actually what John did). If we have incomplete data (period missing) we should get identical results if all data are kept:If incompleted cases are excluded (as sugested by the EMA for nonreplicated studies), any software / model should give the same results anyway. See also there.

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