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RegisterReporting of plasma concentration data etc [Bioanalytics]
Hi both,
This could be the case if there is one or more subjects having some period data missing; didn't I read somewhere that WNL will do a max likelihood optimisation by default (=essentially a mixed model) whereas SAS will try Proc GLM (normal linear model).
The mixed model versus normal linear model would explain the subtle difference which then isn't a matter of decimals carried.
❝ ❝ 2) Lets say you analyze the data with 1) SAS, 2) Winnolin. The SAS result shows a 90% CI of 85.22 - 125.1 and the Winnonlin result shows 85.15 - 124.98????
❝
❝ Are you sure the differences are due to decimal places - I would think it more likely there is some difference in your model settings to explain this - (although of course it's a great advert if WNL can somehow make borderline products BE ;0)
This could be the case if there is one or more subjects having some period data missing; didn't I read somewhere that WNL will do a max likelihood optimisation by default (=essentially a mixed model) whereas SAS will try Proc GLM (normal linear model).
The mixed model versus normal linear model would explain the subtle difference which then isn't a matter of decimals carried.
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Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- Reporting of plasma concentration data etc jag009 2014-09-18 21:32
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Reporting of plasma concentration data etc Ohlbe 2014-09-18 21:50
- Reporting of plasma concentration data etc jag009 2014-09-18 22:22
- Reporting of plasma concentration data etc Ohlbe 2014-09-19 12:26
- Reporting of plasma concentration data etc d_labes 2014-09-19 08:46
- Reporting of plasma concentration data etc nobody 2014-09-19 10:31
- Reporting of plasma concentration data etc jag009 2014-09-19 15:26
- Reporting of plasma concentration data etc nobody 2014-09-19 16:01
- Reporting of plasma concentration data etc jag009 2014-09-26 16:29
- Reporting of plasma concentration data etc nobody 2014-09-19 16:01
- Reporting of plasma concentration data etc jag009 2014-09-19 15:26
- Reporting of plasma concentration data etc nobody 2014-09-19 10:31
- Reporting of plasma concentration data etc jag009 2014-09-18 22:22
- Reporting of plasma concentration data etc SDavis 2014-09-25 15:10
- Reporting of plasma concentration data etc Helmut 2014-09-25 16:11
- Reporting of plasma concentration data etc jag009 2014-09-26 16:22
- Reporting of plasma concentration data etc Ohlbe 2014-09-28 13:53
- Reporting of plasma concentration data etcElMaestro 2014-09-28 15:07
- SAS vs. PHX/WNL Helmut 2014-09-28 17:21
- Numbers should reflect the precision of the instrumentation Helmut 2014-09-28 19:34
- Reporting of plasma concentration data etc Ohlbe 2014-09-18 21:50
Ing. Helmut Schütz