Bioequivalence and Bioavailability Forum • Reporting of plasma concentration data etc

Reporting of plasma concentration data etc [Bioanalytics]

posted by ElMaestro – Denmark, 2014-09-28 17:07 (3892 d 08:15 ago) – Posting: # 13605
Views: 12,665

Hi both,

❝ ❝ 2) Lets say you analyze the data with 1) SAS, 2) Winnolin. The SAS result shows a 90% CI of 85.22 - 125.1 and the Winnonlin result shows 85.15 - 124.98????

❝

❝ Are you sure the differences are due to decimal places - I would think it more likely there is some difference in your model settings to explain this - (although of course it's a great advert if WNL can somehow make borderline products BE ;0)

This could be the case if there is one or more subjects having some period data missing; didn't I read somewhere that WNL will do a max likelihood optimisation by default (=essentially a mixed model) whereas SAS will try Proc GLM (normal linear model).
The mixed model versus normal linear model would explain the subtle difference which then isn't a matter of decimals carried.

—
Pass or fail!
ElMaestro

Complete thread:

Reporting of plasma concentration data etc jag009 2014-09-18 21:32
- Reporting of plasma concentration data etc Ohlbe 2014-09-18 21:50
  - Reporting of plasma concentration data etc jag009 2014-09-18 22:22
    - Reporting of plasma concentration data etc Ohlbe 2014-09-19 12:26
  - Reporting of plasma concentration data etc d_labes 2014-09-19 08:46
    - Reporting of plasma concentration data etc nobody 2014-09-19 10:31
      - Reporting of plasma concentration data etc jag009 2014-09-19 15:26
        
        Reporting of plasma concentration data etc nobody 2014-09-19 16:01
        
        Reporting of plasma concentration data etc jag009 2014-09-26 16:29
- Reporting of plasma concentration data etc SDavis 2014-09-25 15:10
  - Reporting of plasma concentration data etc Helmut 2014-09-25 16:11
  - Reporting of plasma concentration data etc jag009 2014-09-26 16:22
    - Reporting of plasma concentration data etc Ohlbe 2014-09-28 13:53
  - Reporting of plasma concentration data etcElMaestro 2014-09-28 15:07
    - SAS vs. PHX/WNL Helmut 2014-09-28 17:21
- Numbers should reflect the precision of the instrumentation Helmut 2014-09-28 19:34