Bioequivalence and Bioavailability Forum • Reporting of plasma concentration data etc

Reporting of plasma concentration data etc [Bioanalytics]

posted by Ohlbe – France, 2014-09-28 15:53 (3892 d 09:43 ago) – Posting: # 13604
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Hi John,

❝ I used SAS and Phoenix to do the above comparisons. SAS was carried out in Proc GLM.

❝

❝ The only caveat I could think of is the dataset (n=56) because the concentrations were reported in 3 significant figures and have values ranging from 0.xxx to x0.x. Note that for this investigation I only focused in Cmax and not AUC (so to eliminate any differences in computation).

That's still a hell of a difference, and I certainly would not expect it to be that large with n=56. But in any case if the same dataset with the exact same figures was used in SAS and Phoenix, I fail to see how the number of significant figures or decimals could change anything in the 90 % CI ?

—
Regards
Ohlbe

Complete thread:

Reporting of plasma concentration data etc jag009 2014-09-18 21:32
- Reporting of plasma concentration data etc Ohlbe 2014-09-18 21:50
  - Reporting of plasma concentration data etc jag009 2014-09-18 22:22
    - Reporting of plasma concentration data etc Ohlbe 2014-09-19 12:26
  - Reporting of plasma concentration data etc d_labes 2014-09-19 08:46
    - Reporting of plasma concentration data etc nobody 2014-09-19 10:31
      - Reporting of plasma concentration data etc jag009 2014-09-19 15:26
        
        Reporting of plasma concentration data etc nobody 2014-09-19 16:01
        
        Reporting of plasma concentration data etc jag009 2014-09-26 16:29
- Reporting of plasma concentration data etc SDavis 2014-09-25 15:10
  - Reporting of plasma concentration data etc Helmut 2014-09-25 16:11
  - Reporting of plasma concentration data etc jag009 2014-09-26 16:22
    - Reporting of plasma concentration data etcOhlbe 2014-09-28 13:53
  - Reporting of plasma concentration data etc ElMaestro 2014-09-28 15:07
    - SAS vs. PHX/WNL Helmut 2014-09-28 17:21
- Numbers should reflect the precision of the instrumentation Helmut 2014-09-28 19:34