Bioequivalence and Bioavailability Forum

Hi sorry to be late to the conversation but I was intrigued by this part of your question,

❝ 2) Lets say you analyze the data with 1) SAS, 2) Winnolin. The SAS result shows a 90% CI of 85.22 - 125.1 and the Winnonlin result shows 85.15 - 124.98????

Are you sure the differences are due to decimal places - I would think it more likely there is some difference in your model settings to explain this - (although of course it's a great advert if WNL can somehow make borderline products BE ;0)

In all seriousness, if possible, I'd love to see your Phoenix project and corresponding SAS code to see where this difference may have arisen since the results should be identical,

Simon

PS On the more general subject topic I've always used the maximum precision supplied (sure if full precision concs are supplied, some of it maybe 'random' numbers in the decimals but that too should 'round out') and rounded only at the end to minimise compounding of rounding errors.

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