Bioequivalence and Bioavailability Forum • Reporting of plasma concentration data etc

Reporting of plasma concentration data etc [Bioanalytics]

posted by d_labes – Berlin, Germany, 2014-09-19 10:46 (4303 d 09:52 ago) – Posting: # 13538
Views: 14,858

Dear Ohlbe,

❝ I would report the concentrations with 3 significant digits (or more probably 4, actually) but I would calculate AUC with non-rounded concentrations.

I wouldn't do that that way. Imagine you have only the reported values with 3 or 4 significant digits and are going to recalculate the AUC's. You will surely end with some differences which nitpicking QC personal will surely throws you into your face.

See also this thread back into 2008.

—
Regards,

Detlew

Complete thread:

Reporting of plasma concentration data etc jag009 2014-09-18 21:32
- Reporting of plasma concentration data etc Ohlbe 2014-09-18 21:50
  - Reporting of plasma concentration data etc jag009 2014-09-18 22:22
    - Reporting of plasma concentration data etc Ohlbe 2014-09-19 12:26
  - Reporting of plasma concentration data etcd_labes 2014-09-19 08:46
    - Reporting of plasma concentration data etc nobody 2014-09-19 10:31
      - Reporting of plasma concentration data etc jag009 2014-09-19 15:26
        
        Reporting of plasma concentration data etc nobody 2014-09-19 16:01
        
        Reporting of plasma concentration data etc jag009 2014-09-26 16:29
- Reporting of plasma concentration data etc SDavis 2014-09-25 15:10
  - Reporting of plasma concentration data etc Helmut 2014-09-25 16:11
  - Reporting of plasma concentration data etc jag009 2014-09-26 16:22
    - Reporting of plasma concentration data etc Ohlbe 2014-09-28 13:53
  - Reporting of plasma concentration data etc ElMaestro 2014-09-28 15:07
    - SAS vs. PHX/WNL Helmut 2014-09-28 17:21
- Numbers should reflect the precision of the instrumentation Helmut 2014-09-28 19:34