Bioequivalence and Bioavailability Forum

Hi everyone,

I have 2 questions...

1) How should concentration data be reported in terms of the # of signficant digits or decimal places? Which is the proper way?

I received data from the a lab that reports the values in 3 significant figures only and do not take into account the decimal places. Example, if the value is 12.333, they present it as 12.3. If the value is 0.33333, they will report it as 0.333. If the value is 100.203, they will report it as 100.

Is their approach correct or incorrect? I mean what if the 90% ratio is 86.55 - 125.05 and the upper end would have passed if the lab uses 3 decimal places instead of 3 significant figures for data presentation? I think they should report the values in 3 decimal places.

2) Lets say you analyze the data with 1) SAS, 2) Winnolin. The SAS result shows a 90% CI of 85.22 - 125.1 and the Winnonlin result shows 85.15 - 124.98???? I hate this decimal games...

Thanks
John