Bioequivalence and Bioavailability Forum • ~geometric mean of range

~geometric mean of range [Bioanalytics]

posted by Helmut – Vienna, Austria, 2014-06-17 17:11 (3999 d 00:33 ago) – Posting: # 13076
Views: 14,517

Hi Nobody,

❝ I would consider this as a total non-issues.

Really? Imagine following calibrators: 2, 4, 8, 16, 32, 64, and 128.

Low QC: LLOQ < LQC ≤ 3×LLOQ: >2–6
High QC: >75% of ULOQ: >96
Middle QC: x_ar 65, x_geo 16

That’s a huge difference. If we set the MQC to x_ar we have just one calibrator higher than this value and six below.

❝ Only thing to consider: The closer to LLOq, the higher the variabliity, the higher the chance to be outside acceptance range ;-)

Maybe. Maybe not. Due to the geometric progression of calibrators and the commonly applied weighting schemes, the precision is nice, but there might be problems with accuracy…

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Helmut Schütz

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Complete thread:

determining the QC medium haydonat 2012-10-18 00:26
- QC medium: short answer Helmut 2012-10-18 16:14
  - QC medium: short answer ElMaestro 2012-10-18 16:51
- QC medium: lengthy answer Helmut 2012-10-19 15:47
  - QC medium concentration in 2014 Debbie 2014-06-10 19:42
    - ~geometric mean of range Helmut 2014-06-17 14:30
      - ~geometric mean of range nobody 2014-06-17 14:49
        
        ~geometric mean of rangeHelmut 2014-06-17 15:11
        
        ~geometric mean of range nobody 2014-06-17 18:26
        
        ~geometric mean of range Helmut 2014-06-18 16:07
        
        compromise ElMaestro 2014-06-18 17:43
        
        compromise Ohlbe 2014-06-18 20:00
        
        compromise Helmut 2014-06-19 01:13
        
        compromise Ohlbe 2014-06-19 11:15
        
        compromise nobody 2014-06-19 14:10