Chiral Columns [Bioanalytics]

posted by AngusMcLean – USA, 2014-05-24 01:44 (4022 d 19:22 ago) – Posting: # 13004
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Lyn: I have a lot of experience with chiral columns. For the analysis of mixtures of dextro and levoamphetamine in plasma. The plasma extract was an elaborate procedure involving extraction, back-extraction into acid, basifying and then extracting finally into organic solvent. The column we used was a normal phase chiral column so it was like old established normal phase chromatography eluting wiht organic solvents. The sample preparation as always with plasma is the crucial step. We ran lots of samples supporting NDA type studies.

Hope this helps,

Angus

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