bioequivalence study for thiocolchicoside [Bioanalytics]
Hi John,
I think no chance after oral administration:
"Limit of quantification (LOQ): ...The LOQ was found to be 100.82 ng/mL <...>for THC" from P KUMARA,S SHUKLAB, et al.
"Moreover, using a liquid chromatography-MS-MS method, Sutherland et al. found only traces of the parent drug in plasma of healthy volunteers given 8 mg orally (the recommended therapeutic dose). In that study, concentrations were all below 0.30 ng/mL, the lower limit of quantification (LLOQ), apart from the first sampling point, where it was approximately equal to the LLOQ<...> Again, TCC was below the limit of quantification (<1 ng/mL) and only the pharmacologically active metabolite M1 was detected." from M. Trellu et al.
(Emphasis by me)
By the way they recommended to perform PK studies of TCC with a bioanalytical method that can specifically assay both TCC and its metabolite. So everyone can try and look for parent drug
I think no chance after oral administration:
"Limit of quantification (LOQ): ...The LOQ was found to be 100.82 ng/mL <...>for THC" from P KUMARA,S SHUKLAB, et al.
"Moreover, using a liquid chromatography-MS-MS method, Sutherland et al. found only traces of the parent drug in plasma of healthy volunteers given 8 mg orally (the recommended therapeutic dose). In that study, concentrations were all below 0.30 ng/mL, the lower limit of quantification (LLOQ), apart from the first sampling point, where it was approximately equal to the LLOQ<...> Again, TCC was below the limit of quantification (<1 ng/mL) and only the pharmacologically active metabolite M1 was detected." from M. Trellu et al.
(Emphasis by me)
By the way they recommended to perform PK studies of TCC with a bioanalytical method that can specifically assay both TCC and its metabolite. So everyone can try and look for parent drug

—
Kind regards,
Mittyri
Kind regards,
Mittyri
Complete thread:
- bioequivalence study for thiocolchicoside manojskr 2014-02-20 15:07
- bioequivalence study for thiocolchicoside mittyri 2014-02-20 17:51
- bioequivalence study for thiocolchicoside jag009 2014-02-20 21:29
- bioequivalence study for thiocolchicosidemittyri 2014-02-21 06:39
- bioequivalence study for thiocolchicoside manojskr 2014-02-21 14:37
- bioequivalence study for thiocolchicoside jag009 2014-02-20 21:29
- bioequivalence study for thiocolchicoside mittyri 2014-02-20 17:51