bioequivalence study for thio­colchi­coside [Bioanalytics]

posted by mittyri  – Russia, 2014-02-21 07:39 (4115 d 01:37 ago) – Posting: # 12469
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Hi John,

I think no chance after oral administration:
"Limit of quantification (LOQ): ...The LOQ was found to be 100.82 ng/mL <...>for THC" from P KUMARA,S SHUKLAB, et al.

"Moreover, using a liquid chromatography-MS-MS method, Sutherland et al. found only traces of the parent drug in plasma of healthy volunteers given 8 mg orally (the recommended therapeutic dose). In that study, concentrations were all below 0.30 ng/mL, the lower limit of quantification (LLOQ), apart from the first sampling point, where it was approximately equal to the LLOQ<...> Again, TCC was below the limit of quantification (<1 ng/mL) and only the pharmacologically active metabolite M1 was detected." from M. Trellu et al.
(Emphasis by me)

By the way they recommended to perform PK studies of TCC with a bioanalytical method that can specifically assay both TCC and its metabolite. So everyone can try and look for parent drug ;-)

Kind regards,
Mittyri

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