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Registerbioequivalence study for thiocolchicoside [Bioanalytics]
Dear All,
I need to do a bioequivalence study (for EMEA region) for thiocolchicoside in human plasma. Some paper suggests that it is impractical to analyze thiocolchicoside in human plasma as it rapidly converts to its active metabolite 3-desmethylthiocolchicine. Hence, analysis of 3-desmethylthiocolchicine is better for BE evaluation. However, some papers also refer analysis of thiocolchicoside for BE evaluation. Now it is confusing whether thiocolchicoside can realy be detected in human plasma for evaluation of BE or not?
Kindly suggest
Regards,
Manoj K Singh
Edit: Please follow the Forum’s Policy. I deleted another post with identical wording. [Helmut]
I need to do a bioequivalence study (for EMEA region) for thiocolchicoside in human plasma. Some paper suggests that it is impractical to analyze thiocolchicoside in human plasma as it rapidly converts to its active metabolite 3-desmethylthiocolchicine. Hence, analysis of 3-desmethylthiocolchicine is better for BE evaluation. However, some papers also refer analysis of thiocolchicoside for BE evaluation. Now it is confusing whether thiocolchicoside can realy be detected in human plasma for evaluation of BE or not?
Kindly suggest
Regards,
Manoj K Singh
Edit: Please follow the Forum’s Policy. I deleted another post with identical wording. [Helmut]
Complete thread:
- bioequivalence study for thiocolchicosidemanojskr 2014-02-20 15:07
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- bioequivalence study for thiocolchicoside mittyri 2014-02-20 17:51
- bioequivalence study for thiocolchicoside jag009 2014-02-20 21:29
- bioequivalence study for thiocolchicoside mittyri 2014-02-21 06:39
- bioequivalence study for thiocolchicoside manojskr 2014-02-21 14:37
- bioequivalence study for thiocolchicoside jag009 2014-02-20 21:29
- bioequivalence study for thiocolchicoside mittyri 2014-02-20 17:51
Ing. Helmut Schütz