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RegisterAnalyte measured to Lymecycline bioequivalence study [Bioanalytics]
Dear Dr. Dan,
We are also having same concern and had gone through many authentic literatures and papers but could not draw a conclusion that whether we should analyze Lymecycline or Tetracycline. Lymecycline level in plasma, if analyzable, will be our priority. Some of the papers state that Lymecycline is more readily absorbed from the gastro-intestinal tract than tetracycline with a peak serum concentration of approximately 2mg/l after 3 hours following a 300mg dose. After oral dosing it is absorbed readily with or without the presence of food and is excreted slowly in urine. The drug is lipid soluble. The serum half-life of lymecycline is approximately 10 hours.
Another report, Public Assessment Report Lymecycline 408mg capsule,states "a washout period of 7 days is sufficient time for Lymecycline to be eliminated from body. A validated LC-MS/MS analytical methodology was used for quantification of Lymecycline from the human plasma samples. Hence, we need a confirmation that Lymecycline is actualy breaking into Tetracycline in GI tract and is not present in blood for detection at any measurable concentration level.
Kind Regards,
Manoj Singh
We are also having same concern and had gone through many authentic literatures and papers but could not draw a conclusion that whether we should analyze Lymecycline or Tetracycline. Lymecycline level in plasma, if analyzable, will be our priority. Some of the papers state that Lymecycline is more readily absorbed from the gastro-intestinal tract than tetracycline with a peak serum concentration of approximately 2mg/l after 3 hours following a 300mg dose. After oral dosing it is absorbed readily with or without the presence of food and is excreted slowly in urine. The drug is lipid soluble. The serum half-life of lymecycline is approximately 10 hours.
Another report, Public Assessment Report Lymecycline 408mg capsule,states "a washout period of 7 days is sufficient time for Lymecycline to be eliminated from body. A validated LC-MS/MS analytical methodology was used for quantification of Lymecycline from the human plasma samples. Hence, we need a confirmation that Lymecycline is actualy breaking into Tetracycline in GI tract and is not present in blood for detection at any measurable concentration level.
Kind Regards,
Manoj Singh
Complete thread:
- Analyte measured to Lymecycline bioequivalence study Mauricio Sampaio 2013-09-02 15:50
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Analyte measured to Lymecycline bioequivalence study Dr_Dan 2013-09-02 20:53
- Analyte measured to Lymecycline bioequivalence study Mauricio Sampaio 2013-09-03 19:58
- Analyte measured to Lymecycline bioequivalence studymanojskr 2013-09-04 15:06
- Analyte measured to Lymecycline bioequivalence study Dr_Dan 2013-09-04 20:05
- Analyte measured to Lymecycline bioequivalence study manojskr 2013-09-05 05:54
- Analyte measured to Lymecycline bioequivalence study Dr_Dan 2013-09-04 20:05
- Analyte measured to Lymecycline bioequivalence study Dr_Dan 2013-09-02 20:53
Ing. Helmut Schütz