Bioequivalence and Bioavailability Forum • Freeze-thaw studies

Freeze-thaw studies [Bioanalytics]

posted by Helmut – Vienna, Austria, 2013-09-04 16:43 (4283 d 10:57 ago) – Posting: # 11435
Views: 4,458

Hi Martin,

❝ Nope, no "true" initial concentration available (just 3 replicates prior first freezing step).

OK, expected that.

❝ I thought on linear regression and test the slope to be different for zero. However, I do not like this approach for obvious reasons ;-) .

Yes, doesn’t make sense.

❝ Another approach may be to calculate the 95% CI for the mean at step 0 (kind of plausibility interval) and check if CI for the model-predictions is within that interval.

❝ What do you think?

Much better. See also the Hsin-ya’s and Yung-jin’s stab for R.

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Complete thread:

Freeze-thaw studies martin 2013-09-04 11:29
- Freeze-thaw studies Helmut 2013-09-04 13:27
  - Freeze-thaw studies martin 2013-09-04 14:03
    - Freeze-thaw studiesHelmut 2013-09-04 14:43