Bioequivalence and Bioavailability Forum • Analyte measured to Lymecycline bioequivalence study

Analyte measured to Lymecycline bioequivalence study [Bioanalytics]

posted by Mauricio Sampaio – Brazil, 2013-09-02 17:50 (4285 d 02:37 ago) – Posting: # 11409
Views: 9,061

Dear,

in Public Assessment Report of Lymecycline 408 capsules from MHRA (UK/H/1889/002/DC)* the pharmacokinetics results of bioequivalence study of Lymecycline is based on data from Tetracycline and not Lymecycline (page 13). However, in page 10, the Lymecycline is described as active substance.

In this case Lymecycline is a prodrug and serves as a type of precursor to the intended drug (Tetracycline)?

Please, clarify my doubt.

* http://www.mhra.gov.uk/home/groups/par/documents/websiteresources/con205367.pdf

Complete thread:

Analyte measured to Lymecycline bioequivalence studyMauricio Sampaio 2013-09-02 15:50
- Analyte measured to Lymecycline bioequivalence study Dr_Dan 2013-09-02 20:53
  - Analyte measured to Lymecycline bioequivalence study Mauricio Sampaio 2013-09-03 19:58
  - Analyte measured to Lymecycline bioequivalence study manojskr 2013-09-04 15:06
    - Analyte measured to Lymecycline bioequivalence study Dr_Dan 2013-09-04 20:05
      - Analyte measured to Lymecycline bioequivalence study manojskr 2013-09-05 05:54