Analyte measured to Lymecycline bioequivalence study [Bioanalytics]

posted by Mauricio Sampaio  – Brazil, 2013-09-02 17:50 (4675 d 04:50 ago) – Posting: # 11409
Views: 10,620

Dear,

in Public Assessment Report of Lymecycline 408 capsules from MHRA (UK/H/1889/002/DC)* the pharmacokinetics results of bioequivalence study of Lymecycline is based on data from Tetracycline and not Lymecycline (page 13). However, in page 10, the Lymecycline is described as active substance.

In this case Lymecycline is a prodrug and serves as a type of precursor to the intended drug (Tetracycline)?

Please, clarify my doubt.

* http://www.mhra.gov.uk/home/groups/par/documents/websiteresources/con205367.pdf

Complete thread:

UA Flag
Activity
 Admin contact
23,655 posts in 4,993 threads, 1,571 registered users;
124 visitors (0 registered, 124 guests [including 14 identified bots]).
Forum time: 22:41 CEST (Europe/Vienna)

Science is simply common sense at its best that is,
rigidly accurate in observation, and
merciless to fallacy in logic.    Thomas Henry Huxley

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5