Calculation of ISR deviation [Bioanalytics]

posted by Helmut Homepage – Vienna, Austria, 2013-04-25 04:00 (4417 d 03:52 ago) – Posting: # 10493
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Dear Ohlbe,

❝ I was actually thinking of the white paper of the "Crystal City 3.5" meeting of 2008, by Douglas Fast et al.


OK, here we are:

% Difference = 100 × (Repeat – Original) / Mean


❝ Regarding the number of samples, do you know this paper by Hoffman ? Too much stats in it for my brain, but you should be able to understand it better ;-)


I like it. Of course it makes sense to come up with a number of samples depending on the variability. 5 (or 10%) of the study’s samples are arbitrary. Fig. 4 is telling: With a CV of 10% it is simply irrelevant whether 40 or 160 samples are tested.


Edit: R-code in this post.

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