Bioequivalence and Bioavailability Forum • Simulate 5x5x5 cross-over?

Simulate 5x5x5 cross-over? [Design Issues]

posted by ElMaestro – Denmark, 2013-02-02 03:21 (4889 d 05:28 ago) – Posting: # 9948
Views: 7,756

Hi John,

❝ Let me make sure if I am on the right path... The st.dev you referred to is the std.dev of the T/R ratios? What I mean is --> T &R Cmax data from 24 subjects, calculate T/R ratio per subject, caluate mean and SD for T/R ratio, then use the mean and SD from this T/R ratio data to generate the T and R values as you listed above?

Strictly the st.dev. comes from an anova's mean sq. error (model fixed effects Per, Seq, Treatment, Subj; the latter can be a random as well without impact on the outcome in the non-repliacted case) if you have one such. That way you have taken the fixed effects into account for its calculation.

—
Pass or fail!
ElMaestro

Complete thread:

# of sequence for higher order crossover design jag009 2013-01-28 16:01
- # of sequence for 5-tmt-5period design d_labes 2013-01-28 16:37
  - # of sequence for 5-tmt-5period design jag009 2013-01-28 17:18
  - # of sequence for 5-tmt-5period design jag009 2013-01-29 15:12
    - Simulate 5x5x5 cross-over? d_labes 2013-01-29 15:28
      - Simulate 5x5x5 cross-over? jag009 2013-01-29 16:04
        
        Simulate a full replicate study d_labes 2013-01-29 16:52
        
        Simulate a full replicate study jag009 2013-01-29 17:00
        
        Simulate 5x5x5 cross-over? ElMaestro 2013-01-30 10:10
        
        Simulate 5x5x5 cross-over? jag009 2013-01-31 15:31
        
        Simulate 5x5x5 cross-over? ElMaestro 2013-01-31 17:13
        
        Simulate 5x5x5 cross-over? jag009 2013-02-01 15:33
        
        Simulate 5x5x5 cross-over? ElMaestro 2013-02-01 16:50
        
        Simulate 5x5x5 cross-over? jag009 2013-02-01 20:36
        
        Simulate 5x5x5 cross-over?ElMaestro 2013-02-02 02:21
        
        Simulate 5x5x5 cross-over? jag009 2013-02-04 15:06
        
        Sokme? d_labes 2013-02-04 09:05
        
        Some ElMaestro 2013-02-04 11:16