Bioequivalence and Bioavailability Forum • Simulate 5x5x5 cross-over?

Simulate 5x5x5 cross-over? [Design Issues]

posted by jag009 – NJ, 2013-02-01 16:33 (4887 d 05:13 ago) – Posting: # 9944
Views: 7,772

Hi ElMaestro,

❝ I am not sure I follow completely, but by and large this sounds correct, although I would probably prefer to simulate all values (both Test and Ref) rather than just re-using those values you had in the previous study.

This is the part where I am having trouble with. How do you simulate all values instead of re-using what I have from the study? Would the following be correct? Lets me just focus on a crossover study (forget replicate for now)
1) Obtained the mean and SD for AUC, Cmax of each dataset (log?)
2) Randomly generate from normal distribution AUC and Cmax (based on the mean and SD)
3) introduce the withsubject error (method as mentioned in last post) to each value.

Or I better off use T/R ratio for the above instead of using parameters?
I am new to this area so any comment would be very helpful.

Thanks
John

Complete thread:

# of sequence for higher order crossover design jag009 2013-01-28 16:01
- # of sequence for 5-tmt-5period design d_labes 2013-01-28 16:37
  - # of sequence for 5-tmt-5period design jag009 2013-01-28 17:18
  - # of sequence for 5-tmt-5period design jag009 2013-01-29 15:12
    - Simulate 5x5x5 cross-over? d_labes 2013-01-29 15:28
      - Simulate 5x5x5 cross-over? jag009 2013-01-29 16:04
        
        Simulate a full replicate study d_labes 2013-01-29 16:52
        
        Simulate a full replicate study jag009 2013-01-29 17:00
        
        Simulate 5x5x5 cross-over? ElMaestro 2013-01-30 10:10
        
        Simulate 5x5x5 cross-over? jag009 2013-01-31 15:31
        
        Simulate 5x5x5 cross-over? ElMaestro 2013-01-31 17:13
        
        Simulate 5x5x5 cross-over?jag009 2013-02-01 15:33
        
        Simulate 5x5x5 cross-over? ElMaestro 2013-02-01 16:50
        
        Simulate 5x5x5 cross-over? jag009 2013-02-01 20:36
        
        Simulate 5x5x5 cross-over? ElMaestro 2013-02-02 02:21
        
        Simulate 5x5x5 cross-over? jag009 2013-02-04 15:06
        
        Sokme? d_labes 2013-02-04 09:05
        
        Some ElMaestro 2013-02-04 11:16