Bioequivalence and Bioavailability Forum • Simulate 5x5x5 cross-over?

Simulate 5x5x5 cross-over? [Design Issues]

posted by jag009 – NJ, 2013-01-29 17:04 (4891 d 22:43 ago) – Posting: # 9925
Views: 7,976

Hi Detlew,

I think I wrote the question in the wrong thread but I hope that you can help me as well.

In a nutshell here is what I am trying to do. I have a set of data from a parital 3-way replicate study (1 Test, reference given twice). I want to find out what happens if I simulate this to a full replicate study. Therefore I need to
1) Generating a 2nd set of data for the test product
2) I also want to introduce some intrasubject CVs on the test data

Question 1 can be done with bootstrap on the existing data(Correct?). But how should I approach question 2 so that I can see BE/SABE scenarios with different intrasubject CV on the test?

thanks
John

Complete thread:

# of sequence for higher order crossover design jag009 2013-01-28 16:01
- # of sequence for 5-tmt-5period design d_labes 2013-01-28 16:37
  - # of sequence for 5-tmt-5period design jag009 2013-01-28 17:18
  - # of sequence for 5-tmt-5period design jag009 2013-01-29 15:12
    - Simulate 5x5x5 cross-over? d_labes 2013-01-29 15:28
      - Simulate 5x5x5 cross-over?jag009 2013-01-29 16:04
        
        Simulate a full replicate study d_labes 2013-01-29 16:52
        
        Simulate a full replicate study jag009 2013-01-29 17:00
        
        Simulate 5x5x5 cross-over? ElMaestro 2013-01-30 10:10
        
        Simulate 5x5x5 cross-over? jag009 2013-01-31 15:31
        
        Simulate 5x5x5 cross-over? ElMaestro 2013-01-31 17:13
        
        Simulate 5x5x5 cross-over? jag009 2013-02-01 15:33
        
        Simulate 5x5x5 cross-over? ElMaestro 2013-02-01 16:50
        
        Simulate 5x5x5 cross-over? jag009 2013-02-01 20:36
        
        Simulate 5x5x5 cross-over? ElMaestro 2013-02-02 02:21
        
        Simulate 5x5x5 cross-over? jag009 2013-02-04 15:06
        
        Sokme? d_labes 2013-02-04 09:05
        
        Some ElMaestro 2013-02-04 11:16