Use of Naltrexone prior to Naloxone dosing [Design Issues]

posted by jag009  – NJ, 2013-01-10 17:41 (4915 d 06:36 ago) – Posting: # 9818
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Hi,

Yes. If I stand correct it's because naloxone is a weaker antagonist therefore if you give it with an opiate then you will still see withdrawal symptoms. That's why you give naltrexone before hand to prevent withdraws since it's a stronger anatagonist (and longer duration of action). Naloxone alone will not cause withdrawal symptoms.

John

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