Bioequivalence and Bioavailability Forum • Latin Squares ↔ Williams’ designs

Latin Squares ↔ Williams’ designs [Design Issues]

posted by Helmut – Vienna, Austria, 2012-11-06 15:07 (4974 d 15:02 ago) – Posting: # 9513
Views: 6,949

Hi Martin!

❝ I was told that this design is standard for this kind of studies (one test and 2 references) […]

There’s a hint in EMA’s BE GL p.22 (“3 treatment, 3 period, 6 sequence design”). Williams’ designs are variance-balanced for (first-order) carry-over, which should be avoided by a suitable washout anyway. I have learned from Detlew that Latin Squares should do as well.

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Helmut Schütz

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Complete thread:

Replicated cross over with fixed number of periods martin 2012-11-05 17:31
- Additional information martin 2012-11-06 11:50
  - Quick Q for my clarification ElMaestro 2012-11-06 12:09
    - Quick Q for my clarification martin 2012-11-06 12:29
      - 5 periods ElMaestro 2012-11-06 12:43
      - Latin Squares ↔ Williams’ designsHelmut 2012-11-06 14:07
        
        Latin Squares ↔ Williams’ designs Ben 2012-11-07 21:10
        
        Williams’ designs more reliable? d_labes 2012-11-08 08:29
        
        Williams’ designs more reliable? Ben 2012-11-09 18:20
        
        Williams’ designs more reliable? d_labes 2012-11-11 14:14
        
        Williams’ designs more reliable? Ben 2012-11-18 13:20
        
        Frequentists vs. Bayesians Helmut 2012-11-18 14:48
        
        Frequentists vs. Bayesians Ben 2012-11-18 15:28