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RegisterQuick Q for my clarification [Design Issues]
Hi Martin,
why would it be an aim to replicate administration of the test product? Save a period? I ask because I think most sponsors only wish to replicate due to scaling options, and then only replication of the ref. comes into play. Is your situation somehow demanding knowledge of intra-subject variability for all formulations?
Anyways, from a theoretical standpoint I guess the higher order of carry-over is interesting but in my experience agencies aren't too concerned. After all, there are many more obvious assumptions and shortcuts in play when we do BE; mandatory parametric statistics as one example, neglection of nuisance effects as a prominent other example. So in practice carry-over is just something that is of practical concern to you when the girlfriend has spent 9 hours shopping and needs assistance to get 17 bags of clothes transferred to your car in the parking lot.
If your test subjects have long tails and eat cheese then I wouldn't know how it would be assessed, though.
why would it be an aim to replicate administration of the test product? Save a period? I ask because I think most sponsors only wish to replicate due to scaling options, and then only replication of the ref. comes into play. Is your situation somehow demanding knowledge of intra-subject variability for all formulations?
Anyways, from a theoretical standpoint I guess the higher order of carry-over is interesting but in my experience agencies aren't too concerned. After all, there are many more obvious assumptions and shortcuts in play when we do BE; mandatory parametric statistics as one example, neglection of nuisance effects as a prominent other example. So in practice carry-over is just something that is of practical concern to you when the girlfriend has spent 9 hours shopping and needs assistance to get 17 bags of clothes transferred to your car in the parking lot.
If your test subjects have long tails and eat cheese then I wouldn't know how it would be assessed, though.
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Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- Replicated cross over with fixed number of periods martin 2012-11-05 17:31
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Additional information martin 2012-11-06 11:50
- Quick Q for my clarificationElMaestro 2012-11-06 12:09
- Quick Q for my clarification martin 2012-11-06 12:29
- 5 periods ElMaestro 2012-11-06 12:43
- Latin Squares ↔ Williams’ designs Helmut 2012-11-06 14:07
- Latin Squares ↔ Williams’ designs Ben 2012-11-07 21:10
- Williams’ designs more reliable? d_labes 2012-11-08 08:29
- Williams’ designs more reliable? Ben 2012-11-09 18:20
- Williams’ designs more reliable? d_labes 2012-11-11 14:14
- Williams’ designs more reliable? Ben 2012-11-18 13:20
- Frequentists vs. Bayesians Helmut 2012-11-18 14:48
- Frequentists vs. Bayesians Ben 2012-11-18 15:28
- Frequentists vs. Bayesians Helmut 2012-11-18 14:48
- Williams’ designs more reliable? Ben 2012-11-18 13:20
- Williams’ designs more reliable? d_labes 2012-11-11 14:14
- Williams’ designs more reliable? Ben 2012-11-09 18:20
- Williams’ designs more reliable? d_labes 2012-11-08 08:29
- Latin Squares ↔ Williams’ designs Ben 2012-11-07 21:10
- Quick Q for my clarification martin 2012-11-06 12:29
- Quick Q for my clarificationElMaestro 2012-11-06 12:09
- Additional information martin 2012-11-06 11:50
Ing. Helmut Schütz