Bioequivalence and Bioavailability Forum

Dear All,

Test for Urine drug of abuse screen is done during check in of the subjects.
Benzodiazepines are a class of drugs which are generally tested generally in urine drug of abuse screening.

Suppose a study is done on Lorazepam 2.5 mg, a Benzodiazepine, considering a wash out of 07 days (half life 9-16 hrs) and if the test gives a positive result in Period II, should the volunteer be included in the study or excluded.

prescribing info says

Traces of Ativan can be found in urine for at least a week, even at small doses. Sometimes Ativan can be detected for up to a month and a half after use. Of course, Ativan detection depends on the dose of Ativan taken, and if it’s been taken frequently in the past. Ativan addicts and abusers will have a harder time clearing this drug from their system, even after they completely quit taking Ativan.


Regards,
DIXIT