Bioequivalence and Bioavailability Forum • OROS residence time

OROS residence time [Design Issues]

posted by jag009 – NJ, 2012-09-13 21:45 (5032 d 15:21 ago) – Posting: # 9207
Views: 7,156

I hate OROS :angry:

... Especially Nifedipine OROS... In one pilot study we collected feces from subjects who had bowel movement before 24 hours (and noted the time) to determine if the GITS was excreted.

Speaking of Nifedpine OROS(might be applicable to all OROS?), I ran a food effect study High Fibre vs Low Fibre on the reference itself and the PK was different.

John

Complete thread:

OROS residence time ABE1580 2012-09-13 09:55
- OROS residence time Helmut 2012-09-13 14:28
- OROS residence time jag009 2012-09-13 17:34
  - OROS residence time Helmut 2012-09-13 17:45
    - OROS residence timejag009 2012-09-13 19:45
      - OROS residence time ABE1580 2012-09-14 07:56
        
        OROS residence time ABE1580 2012-09-14 11:14
        
        OROS residence time Helmut 2012-09-14 13:58
        
        OROS residence time jag009 2012-09-17 16:47
        
        OROS residence time Helmut 2012-09-17 16:56
    - OROS residence time jag009 2012-09-18 17:11
    - OROS residence time drsinghs 2012-10-05 06:04
      - OROS residence time Ohlbe 2012-10-05 10:40
        
        OROS residence time drsinghs 2012-10-05 12:14
        
        And where? Helmut 2012-10-05 13:34
        
        And where? drsinghs 2012-10-05 14:16
        
        And where? Ohlbe 2012-10-05 16:00
        
        And where? jag009 2012-10-12 23:05