Bioequivalence and Bioavailability Forum

OROS residence time [Design Issues]

posted by Helmut  – Vienna, Austria, 2012-09-13 19:45 (5028 d 13:01 ago) – Posting: # 9205
Views: 7,117

Hi John!

❝ […] But due the nature of the OROS system, you might be able to exclude subjects who went to the bathroom at earlier time (or subjects who use laxative regularly).

If you define “earlier time” in the protocol.^* I haven’t done so in my studies, though I state cases of diarrhea within the first 24 hours as an exclusion criterion. Haven’t thought about regular users of laxatives yet; good idea!

❝ Helmut, What do you think?

About the blanks? SCNR; forget it.

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• “Earlier” is a comparative degree; so earlier compared to what?

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Helmut Schütz


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Complete thread:

• OROS residence time ABE1580 2012-09-13 09:55 
  • OROS residence time Helmut 2012-09-13 14:28
  • OROS residence time jag009 2012-09-13 17:34
    • OROS residence timeHelmut 2012-09-13 17:45
      • OROS residence time jag009 2012-09-13 19:45
        • OROS residence time ABE1580 2012-09-14 07:56
          • OROS residence time ABE1580 2012-09-14 11:14
            • OROS residence time Helmut 2012-09-14 13:58
              • OROS residence time jag009 2012-09-17 16:47
                • OROS residence time Helmut 2012-09-17 16:56
      • OROS residence time jag009 2012-09-18 17:11
      • OROS residence time drsinghs 2012-10-05 06:04
        • OROS residence time Ohlbe 2012-10-05 10:40
          • OROS residence time drsinghs 2012-10-05 12:14
            • And where? Helmut 2012-10-05 13:34
              • And where? drsinghs 2012-10-05 14:16
                • And where? Ohlbe 2012-10-05 16:00
                  • And where? jag009 2012-10-12 23:05