Bioequivalence and Bioavailability Forum • OROS residence time

OROS residence time [Design Issues]

posted by jag009 – NJ, 2012-09-13 19:34 (5034 d 12:41 ago) – Posting: # 9203
Views: 7,374

Hi ABE,

No. You can't do that. I worked with OROS BE studies before and we never drop subjects due to long residence time of the tablet in the guts. But due the nature of the OROS system, you might be able to exclude subjects who went to the bathroom at earlier time (or subjects who use laxative regularly). Helmut, What do you think?

Thanks
John

Complete thread:

OROS residence time ABE1580 2012-09-13 09:55
- OROS residence time Helmut 2012-09-13 14:28
- OROS residence timejag009 2012-09-13 17:34
  - OROS residence time Helmut 2012-09-13 17:45
    - OROS residence time jag009 2012-09-13 19:45
      - OROS residence time ABE1580 2012-09-14 07:56
        
        OROS residence time ABE1580 2012-09-14 11:14
        
        OROS residence time Helmut 2012-09-14 13:58
        
        OROS residence time jag009 2012-09-17 16:47
        
        OROS residence time Helmut 2012-09-17 16:56
    - OROS residence time jag009 2012-09-18 17:11
    - OROS residence time drsinghs 2012-10-05 06:04
      - OROS residence time Ohlbe 2012-10-05 10:40
        
        OROS residence time drsinghs 2012-10-05 12:14
        
        And where? Helmut 2012-10-05 13:34
        
        And where? drsinghs 2012-10-05 14:16
        
        And where? Ohlbe 2012-10-05 16:00
        
        And where? jag009 2012-10-12 23:05