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RegisterOmeprazole [Design Issues]
Dear colleagues,
While literature indicates that omeprazole is a highly variable drug, can anyone help me know the range of CVs (minimum, maximum) for Cmax, AUC0-t and AUC0-inf, particularly, for the comparator/innovator drug, Losec?
Supposing omeprazole is combined with an anti-inflammatory drug i.e. naproxen, will the variablity of omeprazole be reduced? What would be the best design for such fixed dose combination?
Thank you for the kind help.
While literature indicates that omeprazole is a highly variable drug, can anyone help me know the range of CVs (minimum, maximum) for Cmax, AUC0-t and AUC0-inf, particularly, for the comparator/innovator drug, Losec?
Supposing omeprazole is combined with an anti-inflammatory drug i.e. naproxen, will the variablity of omeprazole be reduced? What would be the best design for such fixed dose combination?
Thank you for the kind help.
Complete thread:
- Omeprazolejoyjac 2012-05-15 09:22
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Omeprazole drgunasakaran1 2012-05-15 09:50
- Omeprazole Helmut 2012-05-15 19:00
- Omeprazole pash413 2012-12-06 18:09
- Cmax at tlast Helmut 2012-12-07 15:29
- Omeprazole, widen of Cmax in a normal crossover design? wienui 2016-04-07 11:00
- Omeprazole reference = HVDP Helmut 2016-04-07 12:57
- Omeprazole pash413 2012-12-06 18:09
- Omeprazole Helmut 2012-05-15 19:00
- Omeprazole drgunasakaran1 2012-05-15 09:50
Ing. Helmut Schütz