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RegisterParallel study as pilot for long half life drug [Design Issues]
Dear Dan,
I don't see how I can proceed with a pivtoal crossover study later. The CV (total CV) obtained from the parallel pilot study is not appropriate for estimating the crossover study sample size since one cannot extract the intraCV from the total CV.
The dilemma I have now is timing... If I go with a crossover pilot --> probably 16 day sampling and 30 day washout --> bloody long study...
If I go with parallel study then cost will be a factor... Double edge sword...
John
I don't see how I can proceed with a pivtoal crossover study later. The CV (total CV) obtained from the parallel pilot study is not appropriate for estimating the crossover study sample size since one cannot extract the intraCV from the total CV.
The dilemma I have now is timing... If I go with a crossover pilot --> probably 16 day sampling and 30 day washout --> bloody long study...
If I go with parallel study then cost will be a factor... Double edge sword...
John
Complete thread:
- Parallel study as pilot for long half life drug jag009 2012-05-07 15:13
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Parallel study as pilot for long half life drug Dr_Dan 2012-05-07 16:00
- Parallel study as pilot for long half life drug d_labes 2012-05-07 16:24
- Parallel study as pilot for long half life drugjag009 2012-05-07 18:15
- AUC72 Helmut 2012-05-07 19:31
- AUC72 jag009 2012-05-07 20:15
- AUC72 Dr_Dan 2012-05-08 12:17
- AUC72 jag009 2012-05-10 15:15
- AUC72: NDAs Helmut 2012-05-10 15:56
- AUC72: NDAs jag009 2012-05-14 15:22
- AUC72: NDAs Helmut 2012-05-10 15:56
- AUC72 jag009 2012-05-10 15:15
- AUC72 Dr_Dan 2012-05-08 12:17
- AUC72 jag009 2012-05-07 20:15
- AUC72 Helmut 2012-05-07 19:31
- Parallel study as pilot for long half life drug Dr_Dan 2012-05-07 16:00
Ing. Helmut Schütz