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RegisterSampling times to capture second peak [Design Issues]
Dear all,
If a compound is known to display a first peak around 5 hours and a second one around 12 hours, do you think a study ought to include intensive sampling to characterise the second peak as well as the first? The guidelines don't seem to mention this and I haven't come across mention of this topic on this forum. It seems that most of the time, a second peak is not expected, or the reasons for it are unclear, but when it is expected...?
Thanks,
Clare
If a compound is known to display a first peak around 5 hours and a second one around 12 hours, do you think a study ought to include intensive sampling to characterise the second peak as well as the first? The guidelines don't seem to mention this and I haven't come across mention of this topic on this forum. It seems that most of the time, a second peak is not expected, or the reasons for it are unclear, but when it is expected...?
Thanks,
Clare
Complete thread:
- Sampling times to capture second peakCLR 2012-04-18 06:35
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Sampling times to capture second peak luvblooms 2012-04-18 13:41
- Sampling times to capture second peak CLR 2012-04-23 06:21
- Sampling times to capture second peak Chiku 2012-08-03 13:52
- Sampling times to capture second peak CLR 2012-04-23 06:21
- Sampling times to capture second peak luvblooms 2012-04-18 13:41
Ing. Helmut Schütz