Bioequivalence and Bioavailability Forum

Dear all,
If test or reference product administration to the subjects with two min interval (i.e. 8:0, 8:2, 8:4) & subject will continue to remain fasting condition for atleast 04 hr post dose.
now, my question are
1. It should be necessary in meal distribution to keep two min interval.
for example,
sub.no  dosing time    meal distribution (at least 4 hr after post dose)
1          8.00             12.10
2          8.02             12.12
3          8.04             12.14
2. In crossover study if we given meal in Period-I at 12.10, in that case it should be necessary to give meal in second period at same time as period one (12.10)

Thanks

Regards
vishal

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Edit: Category changed. [HS]