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RegisterSampling volumes [Design Issues]
Dear Amr
It is possbile to carry out kinetic study on rats. However, taking blood samples of same volume may be a concern here. You can go ahead with retro-orbital puncture which can give you up to 4 ml blood. But I am not sure you can get same 4 ml from same animal at all the time points. I prefer it is better to start with a pilot study with 2 or 3 rats and to to see how they respond.
A parallel design is better. Why dont you try the study in rabbits?? Rabbits can give you sufficient amount of blood through marginal ear vein.
It is possbile to carry out kinetic study on rats. However, taking blood samples of same volume may be a concern here. You can go ahead with retro-orbital puncture which can give you up to 4 ml blood. But I am not sure you can get same 4 ml from same animal at all the time points. I prefer it is better to start with a pilot study with 2 or 3 rats and to to see how they respond.
A parallel design is better. Why dont you try the study in rabbits?? Rabbits can give you sufficient amount of blood through marginal ear vein.
Complete thread:
- bioavailability study on rats A-M-R 2011-03-10 14:06
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- bioavailability study on rats ElMaestro 2011-03-10 14:33
- bioavailability study on rats martin 2011-03-10 15:09
- bioavailability study on rats A-M-R 2011-03-16 10:07
- Sampling volumes martin 2011-03-10 16:53
- Sampling volumesmanan 2011-03-11 06:40
Ing. Helmut Schütz