Bioequivalence and Bioavailability Forum

Therapeutic equivalence? [Design Issues]

posted by d_labes  – Berlin, Germany, 2011-02-08 11:37 (5613 d 18:07 ago) – Posting: # 6584
Views: 8,968

Dear PK,

what therapeutic action of an Anti-cancer agent do you expect in healthy volunteers ?

Due to the cytotoxic effects of most Anti-cancer agents it's IMHO unethically to treat healthy volunteers with them. So also a classical BE study (comparing blood/plasma/serum levels is IMHO also not possible in most cases .

Complete thread:

• Therapeutic equivalence kishorpatil 2011-02-08 10:24 
  • Therapeutic equivalence?d_labes 2011-02-08 10:37
    • Therapeutic equivalence? Dr_Dan 2011-02-08 14:40
      • Therapeutic equivalence? d_labes 2011-02-08 14:45
      • Therapeutic equivalence? bjkim97 2011-02-23 11:06
        • Therapeutic equivalence? Dr_Dan 2011-02-28 14:53
          • Therapeutic equivalence? bjkim97 2011-03-03 12:37
    • Therapeutic equivalence? Mauricio Sampaio 2024-06-17 02:21
  • Therapeutic equivalence raghu 2011-02-09 10:07