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RegisterVolume of fluid [Design Issues]
posted by Helmut 
– Vienna, Austria, 2010-12-31 16:55 (5652 d 06:24 ago) – Posting: # 6369
Views: 3,626
Dear Phani!
Convention - which differs between countries. See this thread and please search the forum in the future.
Was never justified, IMHO.
One urban myth is that the volume is related to 250 mL used in the BCS. But: the stomach is never ‘dry’ - contains about 500 mL liquid in the fasted state, and water has a very short half-life… Actually it should guarantee proper swallowing (with too little fluid the formulation may stick to the oesophagus).
❝ What is the reason behind giving 240 ml of water only, after administering the IP?
Convention - which differs between countries. See this thread and please search the forum in the future.
❝ How is this justified.
Was never justified, IMHO.
One urban myth is that the volume is related to 250 mL used in the BCS. But: the stomach is never ‘dry’ - contains about 500 mL liquid in the fasted state, and water has a very short half-life… Actually it should guarantee proper swallowing (with too little fluid the formulation may stick to the oesophagus).
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Volume of fluid Phaneendra.K 2010-12-31 14:54
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Volume of fluidHelmut 2010-12-31 15:55
- Volume of fluid Ohlbe 2010-12-31 16:02
- Volume of fluid Helmut 2010-12-31 16:47
- Volume of fluid Phaneendra.K 2011-01-02 09:29
- No TOFU, IMHO Helmut 2011-01-02 14:46
- Volume of fluid Ohlbe 2010-12-31 16:02
- Volume of fluid manan 2011-01-01 06:19
- Volume of fluidHelmut 2010-12-31 15:55
Ing. Helmut Schütz