Bioequivalence and Bioavailability Forum • NCA = model independent

NCA = model independent [Design Issues]

posted by Helmut – Vienna, Austria, 2010-11-23 14:57 (5690 d 19:08 ago) – Posting: # 6198
Views: 8,245

Dear Kishor!

❝ […] I am very thanks for u r suggestion

Welcome. Please see this post.

❝ […] i did not get what is NCA modeling?

Maybe my phrase ‘… by means of NCA or PK modeling’ was ambigous (‘or’ = the exclusive disjunction ˅). There’s no ‘NCA modeling’. On the contrary NCA (Noncompartmental Analysis) does not assume a particular pharmacokinetic (compartmental) model. The analysis is done by some variant of the trapezoidal rule (AUC, AUMC) and using the observed C_max. For details see one of my lectures. If you calculate the MRT, don’t forget that MRT=AUMC/AUC is only valid for extravascular data; for infusions MRT=AUMC/AUC-t_inf/2 applies.

P.S: Sometimes NCA is called SHAM (Shape, Height, Area, Moments).
Nick Holford usually adds: aka Walt Disney School of PK Methodology. █▓▒░

—
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Helmut Schütz

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Complete thread:

Regarding Time point selection of IV infusion formulation kishorpatil 2010-11-22 04:50
- Time points (infusion) Helmut 2010-11-22 14:42
  - Time points (infusion) kishorpatil 2010-11-23 10:54
    - NCA = model independentHelmut 2010-11-23 13:57
      - Details time points kishorpatil 2010-11-26 09:35
        
        Ballpark figure(s) Helmut 2010-11-26 12:59
        
        Ballpark figure(s) kishorpatil 2010-11-29 11:41
        
        Believes... Helmut 2010-11-29 13:44
        
        Believes... kishorpatil 2010-11-30 05:56
        
        Are you serious? Helmut 2010-11-30 15:38
        
        Are you serious? kishorpatil 2010-12-09 05:10
      - NCA = model independent NewInPK 2011-01-31 05:47