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RegisterTruncated approach for NTI? [Design Issues]
Dear all,
There are a few narrow therapeutic index drugs with prolonged elimination half-life e.g. warfarin, tacrolimus, etc. These are the drugs for which usually tightended interval (90-111.11% for EU and 90-112% for HPFB) is applicable for AUC.
Is it possible to apply truncated approach (sampling till 72 hrs) for these molecules?
Thanks,
Heema Valera
There are a few narrow therapeutic index drugs with prolonged elimination half-life e.g. warfarin, tacrolimus, etc. These are the drugs for which usually tightended interval (90-111.11% for EU and 90-112% for HPFB) is applicable for AUC.
Is it possible to apply truncated approach (sampling till 72 hrs) for these molecules?
Thanks,
Heema Valera
Complete thread:
- Truncated approach for NTI?HV 2010-04-14 18:37
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Why not? Helmut 2010-04-14 18:48
- Why not? HV 2010-04-14 19:19
- Absorption important Helmut 2010-04-14 19:38
- Why not? HV 2010-04-14 19:19
- Why not? Helmut 2010-04-14 18:48
Ing. Helmut Schütz