Bioequivalence and Bioavailability Forum

❝ How to assess the euivalence for Generic Sodium HYALURONATE

❝ Injections for Osteoarthritis?

❝ Is it required only Clinical End Point study or also the Bioequivalence

❝ Study?

1. Do you believe you can show superiority to placebo with this kind of product? You know that there's no clear clinical evidence of efficacy yet.
   
2. No way. The daily turnover of hyalurnic acid are a couple of grams - you will never be able to see a shift against such high endogenous levels.