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RegisterFirst Point Cmax [Design Issues]
posted by Helmut 
– Vienna, Austria, 2010-01-02 16:57 (6016 d 20:06 ago) – Posting: # 4553
Views: 3,507
Dear Chirag!
Difficult to answer. A solution must no necessarily show a faster absorption than a suspension. Sometimes excipients in a suspension enhance absorption, whereas the API in solution precipitates in the stomach.
I would suggest to perform a small pilot study.
❝ I also wish to know whether the reference product which is a suspension can be taken into consideration for Tmax for designing time points of an effervescent tablet.
Difficult to answer. A solution must no necessarily show a faster absorption than a suspension. Sometimes excipients in a suspension enhance absorption, whereas the API in solution precipitates in the stomach.
I would suggest to perform a small pilot study.
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Time points for Effervescent chiragkhatri 2010-01-01 16:51
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- First Point Cmax Helmut 2010-01-01 17:04
- First Point Cmax chiragkhatri 2010-01-02 04:45
- First Point CmaxHelmut 2010-01-02 15:57
- First Point Cmax chiragkhatri 2010-01-02 04:45
- First Point Cmax Helmut 2010-01-01 17:04
Ing. Helmut Schütz