Bioequivalence and Bioavailability Forum • EMEA at its best

EMEA at its best [Design Issues]

posted by drmuneesh – 2009-08-24 15:59 (6151 d 16:05 ago) – Posting: # 4102
Views: 7,670
(edited on 2009-08-24 16:48)

Dear Helmut and All

How can I safely conduct a bioequivalence study of Rivastigmine Tartrate on 6 mg strength in healthy volunteers. Dimenhydrinate injection is not available in India and other drugs effective in preventing nausea and vomiting with cholinesterase inhibitors (rivastigmine) could be ondansetron, glycopyrrolate, trimethobenzamide or trihexyphenidyl as per some literature. But I don't know which one is the best to complete the study safely.

Please suggest if anybody has experience of administering Rivastigmine 6 mg in healthy volunteers.

Regards
Muneesh

Complete thread:

BE study of Rivastigmine 6 mg in healthy volunteers drmuneesh 2009-08-21 10:59
- Rivastigmine 6 mg: patients? Helmut 2009-08-21 23:17
  - Rivastigmine 6 mg: patients? drmuneesh 2009-08-22 06:51
    - Rivastigmine 6 mg (EU centralised procedure) Helmut 2009-08-22 13:56
    - Rivastigmine 6 mg: patients? ElMaestro 2009-08-22 17:47
      - EMEA at its best Helmut 2009-08-22 18:37
        
        EMEA at its best ElMaestro 2009-08-22 19:17
        
        EMEA at its bestdrmuneesh 2009-08-24 13:59
        
        EMEA at its best drcampos 2009-08-24 19:26
        
        EMEA at its best drmuneesh 2009-08-25 06:12
        
        Rivastigmine BE Dr Lalit 2009-08-25 14:41
        
        Rivastigmine BE drmuneesh 2009-08-26 06:29