Bioequivalence and Bioavailability Forum

Dear Joy,

with a little algebra you can calculate CV_intra from confidence intervals (CIs) and the sample size given in any published study.

Roldán EJ, Quattrocchi O, Zanetti D, Piccinni E, Tessler J, Caballero LE, Lloret AP
In vitro and in vivo equivalence studies of alendronate monosodium tablets
Arzneimittelforschung / Drug Res. 2005; 55/2: 93-101

Urine, 23 subjects:
Ae_0-36h: CI 72%-122% (CVintra 55.7%)

Almeida S, Almeida A, Filipe A, Penedo C, Rocha A, Lainesse A, Vallée F
In vitro disintegration and dissolution and in vivo bioequivalence of two alendronate once-weekly formulations
Arzneimittelforschung / Drug Res. 2006; 56/2: 84-89

Urine, 70 subjects
Ae_0-36h: CI 98.67%-118.99% (CVintra 34.2%)
R_max: CI 102.22%-122.46% (CVintra 32.9%)
CV 32-35% (stated in reference)

Yun MH, Woo JS, Kwon KI
Bioequivalence and pharmacokinetics of 70 mg alendronate sodium tablets by measuring alendronate in plasma
Arch Pharm Res. 2006 Apr; 29/4: 328-332
online resource (1.99MB PDF)

Plasma, 24 subjects:
AUC_0-7h: CI 82.34%-115.97% (CVintra 35.6%)
C_max: CI 82.22%-114.09% (CVintra 34.0%)