Bioequivalence and Bioavailability Forum

Dear Muneesh,

❝ 2. BMI range of 18 and 25 is usually followed in adults to see their

❝ health status. But in the age group of 45-65, females with BMI range of 18

❝ and 25 is very difficult to get. And there is no published literature showing

❝ influence of the BMI on the endpoint. So please suggest what to do.

You are right; according to WHO ( Technical Report Series 854, Chapter 7, 317-318 (1995)):
'Age and Sex. In many affluent countries the prevalence of grades 1 and 2 overweight in men increases with age up to about 55 years, then levels off before finally decreasing somewhat in old age. In women, prevalence continues to rise until old age and then levels off. [...] In postmenopausal woman, and to a lesser degree in men, BMI increases with age even when body weight remains stable, because of age-associated decline in stature. Although age-specific BMI is usually lower in premenopausal than in men, the overall prevalence of overweight is generally higher in women.'

If it's a cross-over study, why don't you set your upper limit of the BMI to e.g., 29?

P.S.: Don't use UTF in you posts (the forum's XHTML Code Page is ISO-8859-1).