Bioequivalence and Bioavailability Forum • Tacrolimus Protocol Queries

Tacrolimus Protocol Queries [Design Issues]

posted by chidambarajoshi – Hyderabad-INDIA, 2008-12-03 06:20 (6413 d 23:01 ago) – Posting: # 2868
Views: 4,936
(edited on 2008-12-03 06:32)

Dear Rahul

❝ I have some articles on BE study of Tacrolimus, some of which have 14 days wash-out period and others 21 days...

Yes..!
But 14 days will always have carry over in pre-dose sample of period-II (I had experienced). So I strongly recommend 21 days where there will not be carryover. B'coz it's RBC bound drug.
And t1/2: 34.8 ± 11.4. So if you consider 10 times of t1/2 it will approx 20 days.

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Best Regards
Joshi

Complete thread:

Tacrolimus Protocol Queries Rahul 2008-12-01 06:59
- Tacrolimus Protocol Queries chidambarajoshi 2008-12-01 07:33
  - Tacrolimus Protocol Queries Rahul 2008-12-01 11:03
    - Tacrolimus Protocol Queries chidambarajoshi 2008-12-02 06:23
      - Tacrolimus Protocol Queries Rahul 2008-12-02 13:32
- Tacrolimus Protocol Queries BEAZ 2008-12-02 07:21
  - Tacrolimus Protocol Queries chidambarajoshi 2008-12-02 09:10
  - Tacrolimus Protocol Queries Rahul 2008-12-02 13:42
    - Tacrolimus Protocol Querieschidambarajoshi 2008-12-03 05:20
      - Estimation of wash-out Helmut 2008-12-03 07:48
    - Tacrolimus Protocol Queries BEAZ 2008-12-03 07:31