Bioequivalence and Bioavailability Forum

Tacrolimus Protocol Queries [Design Issues]

posted by chidambarajoshi – Hyderabad-INDIA, 2008-12-02 07:23 (6420 d 07:12 ago) – Posting: # 2850
Views: 4,920

Dear Rahul,

❝ Expected Pharmacokinetics:-

❝ 1. Tmax: 1.6 + 0.7 hrs

❝ 2. Cmax: 29.7 + 7.2 ng/ml

❝ 3. t1/2: 34.8 + 11.4

For this you may require 3-3.5 mL of blood (for both aliquotes). You can use Sirolimus as IS for BA methoh. Pl refer the following paper for method. It's my paper
Chromatogr B Analyt Technol Biomed Life Sci. 2004 Jun 5;805 (1):13-20
Regards
Joshi

Complete thread:

• Tacrolimus Protocol Queries Rahul 2008-12-01 06:59 
  • Tacrolimus Protocol Queries chidambarajoshi 2008-12-01 07:33
    • Tacrolimus Protocol Queries Rahul 2008-12-01 11:03
      • Tacrolimus Protocol Querieschidambarajoshi 2008-12-02 06:23
        • Tacrolimus Protocol Queries Rahul 2008-12-02 13:32
  • Tacrolimus Protocol Queries BEAZ 2008-12-02 07:21
    • Tacrolimus Protocol Queries chidambarajoshi 2008-12-02 09:10
    • Tacrolimus Protocol Queries Rahul 2008-12-02 13:42
      • Tacrolimus Protocol Queries chidambarajoshi 2008-12-03 05:20
        • Estimation of wash-out Helmut 2008-12-03 07:48
      • Tacrolimus Protocol Queries BEAZ 2008-12-03 07:31