Bioequivalence and Bioavailability Forum

Full Replicate with 3 periods [Design Issues]

posted by mittyri  – Russia, 2023-03-28 00:16 (778 d 04:03 ago) – Posting: # 23514
Views: 4,785

Dear Achievwin!

❝ Can TRT, RTR be called two sequence full replicate in three way cross over?

I would say in three periods. For me 'a way' is closer to the sequence (subject's way ). But that's just my feeling, I see many people are using it, so your wording is rather correct.

❝ can it be a substitute for RTRT or TRTR, or TTRR or RRTT (in four period fully replicated design)?

Hey! Look at the fresh FDA draft
Bloody partial replicate goes away and is being substituted to that design in GL. I would opt for it.

Complete thread:

• Definition of Full Re­pli­cate Sereng 2023-03-13 17:08 
  • Definition of Full Replicate Mahmoud 2023-03-13 20:27
    • Definition of Full Replicate Sereng 2023-03-13 23:38
      • Definition of Full Replicate Mahmoud 2023-03-14 08:44
        • Definition of Full Replicate Achievwin 2023-03-27 19:08
          • Full Replicate with 3 periodsmittyri 2023-03-27 22:16
            • Full Replicate with 3 periods Achievwin 2023-03-28 03:06
            • Full Replicate with 3 periods Helmut 2023-03-28 09:03
  • Definition of Full Replicate Brus 2023-03-14 10:10
  • Replicate Design ≠ Higher-Order Cross­over Helmut 2023-03-14 10:37
    • Thank You! Sereng 2023-03-14 20:08
    • Replicate Design ≠ Higher-Order Cross­over Relaxation 2023-03-20 08:56
      • imbalance in Latin Square mittyri 2023-03-27 23:01
      • Balance for all effects Helmut 2023-04-21 10:01